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Ofloxacin induced hypomania.

Siddharth Sarkar1, Sudhir Kumar Khandelwal

  • 1Senior Resident, Department of Psychiatry, PGIMER , Chandigarh, India .

Journal of Clinical and Diagnostic Research : JCDR
|September 3, 2013
PubMed
Summary

Fluoroquinolone antibiotics, like ofloxacin, can cause central nervous system side effects. One patient experienced hypomania, characterized by elevated mood and reduced sleep, which resolved after stopping the antibiotic.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Fluoroquinolones are broad-spectrum antibiotics with known central nervous system (CNS) side effects.
  • Adverse CNS effects associated with fluoroquinolones can range from mild to severe.

Purpose of the Study:

  • To report a case of hypomania induced by ofloxacin.
  • To highlight the potential neuropsychiatric adverse effects of fluoroquinolones.

Main Methods:

  • Case report presentation.
  • Clinical observation and documentation of patient symptoms and response to medication withdrawal.

Main Results:

  • The patient developed classic hypomanic symptoms including elevated mood, increased talkativeness, decreased need for sleep, and grandiosity.
Keywords:
Affective symptomsFluoroquinolonesHypomaniaOfloxacin

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  • These symptoms were directly linked to the initiation of ofloxacin therapy.
  • Discontinuation of ofloxacin led to the complete resolution of the hypomanic episode.

    • Conclusions:

    • Ofloxacin, a fluoroquinolone antibiotic, can precipitate hypomanic episodes in susceptible individuals.
    • Clinicians should be aware of the potential for neuropsychiatric adverse effects when prescribing fluoroquinolones.
    • Monitoring for CNS side effects is crucial during fluoroquinolone treatment.