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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

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Published on: February 18, 2015

Can new dentures decrease Candida levels?

Tatiana Pereira-Cenci, Frederico S F Fernandes, Jovito A Skupien

The International Journal of Prosthodontics

|September 3, 2013

Summary

Replacing dentures initially reduced oral Candida species, but levels returned to baseline within 6 months for all denture types. Denture material did not significantly impact Candida colonization over time.

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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Area of Science:

Oral microbiology
Prosthodontics
Infectious diseases

Background:

Candida species are common oral inhabitants.
Removable dentures can harbor Candida, increasing the risk of oral candidiasis.
Understanding denture type and time-course effects on Candida colonization is crucial for oral health management.

Purpose of the Study:

To investigate the impact of different removable denture types on oral Candida levels.
To analyze the time-course changes in Candida colonization after denture replacement.
To assess the long-term effectiveness of denture replacement in controlling oral Candida.

Main Methods:

Prospective clinical trial with 72 participants.
Categorization into three groups: Kennedy Class I/II RPDs, Kennedy Class III/IV RPDs, and complete dentures.
Collection of saliva and biofilm samples from oral sites and dentures at baseline, 1, 6, and 12 months post-delivery.
Statistical analysis using three-way ANOVA and Student-Newman-Keuls test.

Main Results:

A temporary decrease in Candida levels was observed immediately after new denture insertion.
Candida levels reverted to baseline by 6 months across all denture types.
Complete denture wearers exhibited higher Candida counts compared to removable partial denture (RPD) wearers at 6 and 12 months.

Conclusions:

Denture type is not a primary determinant of oral Candida levels.
Candida colonization becomes established on all removable prostheses within 6 months.
Denture replacement alone is insufficient for sustained reduction of Candida levels beyond 6 months.