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Recurrent fevers and failure to thrive in an infant

David R Scott1, Sarah Chan, Johanna Chang

  • 1Scripps Clinic, Department of Medicine, San Diego, CA 92130, USA. deardrscott@gmail.com

Allergy and Asthma Proceedings
|September 4, 2013
PubMed

Insights

This case study details a young boy with recurrent fevers, arthritis, and diarrhea, highlighting a rare immunodeficiency. Early diagnosis and treatment are crucial for managing complex pediatric inflammatory conditions.

Area of Science:

  • Pediatric immunology
  • Clinical genetics
  • Infectious diseases

Background:

  • Recurrent fevers, arthritis, and failure to thrive in infants can indicate underlying immune system dysfunction.
  • Consanguinity and geographic origin (India) may suggest specific genetic predispositions.

Observation:

  • A 2-year-old boy presented with oral ulcers, lymphadenopathy, chronic diarrhea, developmental delay, and polyarticular arthritis.
  • Herpes simplex virus 1 viremia and osteopenia with joint erosions were identified.

Findings:

  • The patient exhibited symptoms suggestive of a primary immunodeficiency disorder.
  • Comprehensive immunologic and genetic evaluations were performed to identify the specific condition.

Implications:

  • This case underscores the importance of a thorough diagnostic approach for infants with complex, recurrent symptoms.
  • Understanding the immunologic and genetic basis is key for effective therapeutic strategies in pediatric inflammatory diseases.

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