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Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
Published on: October 17, 2015
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease
Andrew B Wolf1, Jon Valla2, Guojun Bu3
1Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, 12631 E 17th Avenue, AO1 Room 2601, Mail Stop B176, Aurora, CO 80045, USA.
Abstract:
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.
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