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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Emerging therapeutic options in GERD
Philip Woodland1, Gehanjali Amarasinghe, Daniel Sifrim
1Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Best Practice & Research. Clinical Gastroenterology
|September 4, 2013
Summary
Gastroesophageal reflux disease (GERD) treatments like proton pump inhibitors are effective for many. However, refractory GERD cases and surgical side effects necessitate exploring novel pharmacological and non-pharmacological therapies.
Area of Science:
- Gastroenterology
- Pharmacology
- Surgical Innovation
Background:
- Gastroesophageal reflux disease (GERD) is a common condition with significant healthcare costs.
- Standard treatments, including proton pump inhibitors, are effective for most patients.
- A subset of GERD patients exhibit refractory symptoms or experience side effects from laparoscopic fundoplication.
Purpose of the Study:
- To review emerging pharmacological therapies for refractory GERD.
- To discuss non-pharmacological treatment alternatives to laparoscopic fundoplication.
- To address the unmet need for improved GERD management strategies.
Main Methods:
- Literature review of current pharmacological treatments for GERD.
- Analysis of emerging non-pharmacological therapeutic approaches.
- Discussion of novel strategies for managing refractory GERD cases.
Main Results:
- Proton pump inhibitors are the mainstay but do not benefit all GERD patients.
- Laparoscopic fundoplication can cause side effects like dysphagia and gas-bloat.
- Several new pharmacological and non-pharmacological therapies are under investigation for GERD.
Conclusions:
- There is a significant need for new GERD therapies due to treatment resistance and surgical limitations.
- Emerging treatments offer potential alternatives with improved efficacy and reduced side effects.
- Further research is crucial to validate and implement novel GERD management options.
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