[Intrinsic radiosensitivity: predictive assays that will change daily practice].

Area of Science:

• Radiobiology
• Radiation Oncology
• Medical Physics

Context:

• Radiotherapy aims for homogenous dose delivery to target volumes.
• Dose to surrounding healthy tissues impacts treatment efficacy and toxicity.
• Individual radiosensitivity contributes to variable late side effects in patients.

Purpose:

• To review radiobiological approaches for understanding radiation-induced late effects.
• To explore the clinical utility of predictive assays for radiosensitivity.

Summary:

• This review examines radiobiological methods to elucidate mechanisms of radiation-induced late effects.
• It highlights the existence of individual radiosensitivity influencing non-reversible side effects.
• The potential clinical application of predictive assays is also discussed.

Impact:

• Improved understanding of radiation-induced late effects.
• Potential for personalized radiotherapy through predictive assays.
• Enhanced therapeutic ratio in radiation treatments.