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IBS: Autonomic dysregulation in IBS
1Department of Behavioural Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Nature Reviews. Gastroenterology & Hepatology
|September 4, 2013
Summary
Patients with Irritable Bowel Syndrome (IBS) show a reduced autonomic nervous system response to colonic procedures like flexible sigmoidoscopy. This finding is crucial for understanding visceral perception in IBS patients.
Area of Science:
- Gastroenterology and Autonomic Neuroscience
Background:
- Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder.
- Autonomic nervous system (ANS) dysfunction is increasingly recognized in IBS pathophysiology.
Discussion:
- Flexible sigmoidoscopy can elicit colonic stimulation.
- Cheng et al. investigated the cardiac sympathetic and vagal response during this procedure in IBS patients.
Key Insights:
- Patients with IBS exhibit a blunted cardiac sympathetic and vagal response to colonic stimulation during flexible sigmoidoscopy.
- This impaired autonomic response may contribute to altered visceral perception in IBS.
Outlook:
- Further research is needed to elucidate the precise mechanisms linking ANS dysfunction and visceral hypersensitivity in IBS.
- Understanding these responses could lead to novel therapeutic strategies targeting autonomic pathways in IBS management.
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