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Updated: May 8, 2026

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
Published on: September 15, 2023
Oncometabolites: linking altered metabolism with cancer
Ming Yang1, Tomoyoshi Soga, Patrick J Pollard
1Cancer Biology and Metabolism Group, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
None:
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
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