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Updated: May 8, 2026

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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Published on: May 18, 2022

[Hormesis: What doesn't kill you makes you stronger].

Norma Edith López-Diazguerrero¹, Viridiana Yazmín González Puertos, René José Hernández-Bautista

¹Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, D.F. mkf@xanum.uam.mx.

Gaceta Medica De Mexico

|September 4, 2013

Summary

Organisms survive harsh conditions through hormesis, a process where low stress activates defenses against higher stress. This adaptive response involves protective genes and proteins, crucial for resilience.

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Area of Science:

Cellular biology
Environmental stress response
Evolutionary biology

Context:

Organisms face constant environmental challenges.
Survival necessitates adaptive mechanisms.
Hormesis is an evolutionarily conserved survival strategy.

Purpose:

To review the concept of hormesis.
To explore hormesis during oxidative stress.
To link hormesis to aging and disease.

Summary:

Hormesis is a biological response to low-dose stress.
It involves gene expression for cytoprotective proteins (e.g., heat-shock proteins, antioxidants).
Key hormetic agents include irradiation, heat, and oxidative challenges.

Impact:

Understanding hormesis offers insights into cellular resilience.
Hormesis may play a role in aging and age-related diseases.
This review focuses on oxidative stress, senescence, and diseases like diabetes and neurodegeneration.