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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
Published on: June 13, 2010
Array sensing using optical methods for detection of chemical and biological hazards
Katharine L Diehl1, Eric V Anslyn
1Department of Chemistry and Biochemistry, The University of Texas, Austin, TX 78712, USA. Anslyn@austin.utexas.edu.
Chemical Society Reviews
|September 4, 2013
Summary
Artificial receptor arrays mimic mammalian senses for chemical detection. Optical detection and pattern recognition enable sensitive identification of unknown analytes and hazards.
Area of Science:
- Biomimetic sensor technology
- Analytical chemistry
- Chemical sensing
Background:
- Artificial arrays with cross-reactive receptors mimic mammalian taste and smell.
- Pattern recognition algorithms enhance analyte discrimination and identification.
- Optical detection offers high sensitivity and convenient instrumentation for sensing assays.
Purpose of the Study:
- To introduce array sensing using optical detection and chemometrics.
- To review progress in detecting chemical and biological hazards using these methods.
Main Methods:
- Utilizing artificial arrays of cross-reactive receptors.
- Employing pattern recognition algorithms for data analysis.
- Focusing on optical detection as the signaling method.
Main Results:
- Demonstrated ability of artificial arrays to discriminate and identify analytes.
- Highlighted the advantages of optical detection for sensitive and convenient sensing.
- Reviewed advancements in applying these techniques for hazard detection.
Conclusions:
- Array sensing with optical detection and chemometrics is a powerful tool for chemical and biological hazard detection.
- Mimicking biological senses provides a robust platform for advanced analytical applications.
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