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Updated: May 8, 2026
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy
M Rieken1, L A Kluth, E Xylinas
11] Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA [2] Department of Urology, University Hospital Basel, Basel, Switzerland.
Background:
The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.
Methods:
We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni- and multivariable cox regression models addressed the association of statin use with BCR.
Results:
Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values 0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.
Conclusions:
In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.
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