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Aeroallergen sensitization in childhood asthmatics in northern India

Dinesh Raj1, Rakesh Lodha, Anibha Pandey

  • 1Division of Pediatric Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029; *Institute of Genomics and integrative Biology, Mall Road, Delhi. Correspondence to Dr Rakesh Lodha, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India 110029. rakesh_lodha@hotmail.com.

Indian Pediatrics
|September 4, 2013
PubMed

Insights

More than half of asthmatic children show sensitization to common allergens like housefly and rice dust. Atopic children had higher FENO levels, indicating more severe asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Environmental Health

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Allergen sensitization plays a significant role in asthma development and severity.
  • Understanding allergen prevalence is crucial for effective asthma management.

Purpose of the Study:

  • To determine the prevalence of sensitization to common aeroallergens in asthmatic children.
  • To investigate differences in characteristics between atopic and non-atopic asthmatic children.

Main Methods:

  • Prospective cohort study analysis.
  • Involved 180 asthmatic children aged 5-18 years.
  • Utilized skin prick testing (SPT) and fractional exhaled nitric oxide (FENO) measurements.

Main Results:

  • 55.6% of children were sensitized to at least one aeroallergen.
  • Housefly antigen (36.7%) and rice grain dust (31.1%) were the most common sensitizers.
  • Atopic children exhibited significantly higher median FENO levels (17.5 ppb vs 13 ppb).

Conclusions:

  • Over half of asthmatic children in the study cohort demonstrated atopy.
  • Sensitization to housefly antigen and rice grain dust was most prevalent.
  • Higher FENO levels in atopic children suggest a link to asthma severity.
Abstract

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