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Controlled cell adhesion on poly(dopamine) interfaces photopatterned with non-fouling brushes
Cesar Rodriguez-Emmenegger1, Corinna M Preuss, Basit Yameen
1Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstrasse 18, 76131, Karlsruhe, Germany; Zell- und Neurobiologie, Zoologisches Institut, Karlsruhe Institute of Technology (KIT), Haid-und-Neu-Str. 9, Karlsruhe and Institut für Funktionelle Grenzflächen (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Abstract:
Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.
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