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Related Concept Videos

Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...

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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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Published on: August 6, 2019

Multi-modal switching in responsive DNA block co-polymer conjugates.

Gökçen Yaşayan1, Johannes P Magnusson, Giovanna Sicilia

  • 1School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. cameron.alexander@nottingham.ac.uk.

Physical Chemistry Chemical Physics : PCCP
|September 4, 2013
PubMed
Summary
This summary is machine-generated.

New DNA-polymer conjugates with thermoresponsive chains show reversible self-assembly and controlled structural changes. These advanced materials demonstrate potential as drug delivery systems for cancer therapy.

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Published on: December 29, 2021

Area of Science:

  • Bioconjugate Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Development of novel drug delivery systems is crucial for targeted cancer therapy.
  • Stimuli-responsive polymers offer tunable properties for advanced biomaterials.
  • DNA nanotechnology provides a platform for precise molecular assembly.

Purpose of the Study:

  • To synthesize and characterize novel DNA block co-polymer conjugates.
  • To investigate the stimuli-responsive self-assembly and conformational changes of these conjugates.
  • To evaluate the potential of these conjugates as doxorubicin delivery systems for cancer treatment.

Main Methods:

  • Synthesis of DNA block co-polymer conjugates with poly(tri(ethylene glycol)ethyl ether methacrylate) (pTriEGMA) chains.
  • Dynamic Light Scattering (DLS) and Atomic Force Microscopy (AFM) for structural analysis.
  • Evaluation of reversible self-assembly, conformational changes, and linker cleavage.

Main Results:

  • Successfully synthesized DNA-pTriEGMA conjugates with bioreducible or non-reducible links.
  • Demonstrated reversible self-assembly into supramolecular structures triggered by pTriEGMA phase transition.
  • Observed switchable size and association behavior upon addition of competing DNA or reductive cleavage.
  • Preliminary in vitro studies showed good tolerability and doxorubicin-mediated cytotoxicity in a cancer cell line.

Conclusions:

  • The synthesized DNA-polymer conjugates exhibit tunable self-assembly and responsiveness.
  • These conjugates show promise as adaptable platforms for targeted drug delivery in cancer therapy.