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Updated: May 8, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
Thromboangiitis obliterans successfully treated with phosphodiesterase type 5 inhibitors
Aryeh M Abeles1, Mirela Nicolescu2, Zachary Pinchover2
1Division of Rheumatology, University of Connecticut Health Center, Farmington, CT, USA aabeles@uchc.edu.
Abstract:
Thromboangiitis obliterans, or Buerger's disease, is a non-atherosclerotic, segmental, inflammatory disease affecting the small- and medium-sized vessels of the distal extremities. Other than discontinuation of tobacco, there is no standard-of-care treatment. Although two randomized trials have demonstrated a role for intravenous iloprost, no oral drug has yet been demonstrated to be effective in treating thromboangiitis obliterans. We present the first three reported cases of thromboangiitis obliterans successfully treated with phosphodiesterase type 5 inhibitors, followed by a discussion of the rationale for the use of these agents in thromboangiitis obliterans.
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