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Related Experiment Video

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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Default network connectivity as a vulnerability marker for obsessive compulsive disorder.

Z W Peng¹, T Xu¹, Q H He²

¹Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.

Psychological Medicine

|September 5, 2013

Summary

This summary is machine-generated.

Default network connectivity disruptions are linked to obsessive compulsive disorder (OCD). Reduced connectivity in OCD patients and their siblings may indicate a potential genetic marker for the disorder.

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Area of Science:

Neuroscience
Psychiatry
Genetics

Background:

Default mode network (DMN) functional connectivity alterations are implicated in obsessive compulsive disorder (OCD) pathophysiology.
The genetic underpinnings of DMN connectivity in OCD are not well understood.

Purpose of the Study:

To investigate DMN connectivity profiles in OCD patients and their unaffected siblings.
To explore the relationship between abnormal DMN connectivity and genetic risk in OCD.

Main Methods:

Systematic investigation of DMN connectivity.
Comparison of 15 OCD patients, 15 unaffected siblings, and 28 healthy controls.

Main Results:

OCD patients showed reduced DMN connectivity with the posterior cingulate cortex (PCC) and increased connectivity in other brain regions compared to controls.
Unaffected siblings exhibited reduced local PCC connectivity.

Conclusions:

Disrupted DMN functional connectivity may be associated with a family history of OCD.
Decreased DMN connectivity in patients and siblings could serve as a potential biomarker for OCD.