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Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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Introduction to Innate and Adaptive Immunity

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Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

B Cell Activation and Differentiation

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Related Experiment Video

Updated: May 8, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Innate lymphoid cells and allergic inflammation.

Brian S Kim¹, Elia D Tait Wojno, David Artis

¹Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Current Opinion in Immunology

|September 5, 2013

Summary

Group 2 innate lymphoid cells (ILC2s) are crucial for immunity and tissue repair but also drive allergic inflammation. Understanding their regulation offers new therapeutic targets for allergic diseases.

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Last Updated: May 8, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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Published on: May 10, 2022

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Published on: April 16, 2019

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Area of Science:

Immunology
Cell Biology

Background:

Group 2 innate lymphoid cells (ILC2s) are vital for anti-helminth immunity and airway repair.
ILC2s are increasingly recognized for their role in allergic inflammation across various barrier surfaces.

Purpose of the Study:

To review recent advances in understanding ILC2 regulation in allergic inflammation.
To explore the therapeutic potential of targeting ILC2s for allergic diseases.

Main Methods:

Literature review focusing on ILC2s, allergic inflammation, and therapeutic targets.

Main Results:

ILC2s are derived from bone marrow progenitors and rely on transcription factors RORα, GATA3, and TCF-1.
ILC2s produce type 2 cytokines (IL-4, IL-5, IL-9, IL-13).
Epithelial cytokines (IL-25, IL-33, TSLP) regulate ILC2 activation, with tissue environment influencing responsiveness.

Conclusions:

ILC2s are differentially regulated in allergic inflammation based on their tissue context.
Targeting ILC2s presents a promising therapeutic strategy for treating allergic conditions.