[Effect of nitrous oxide on myocardial activity and blood supply in patients with ischemic heart disease]

The effect of N2O at a concentration of 66 vol.% on hemodynamic parameters and myocardial oxygen supply has been studied in 46 patients with ischemic heart disease, functional class III-IV. A marked disbalance between heart work and myocardial O2 consumption manifested in a drop of blood pressure, stroke index, left ventricular stroke index, coronary perfusion pressure with retention of baseline global coronary flow, which may be indicative of the onset of "steal syndrome" in ischemic zones. Therefore, it is recommended not to use N2O in patients with severe coronary pathology.