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Related Experiment Video

Updated: May 8, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Vitiligo: is it grace or curse?

Ola Ahmed Bakry¹, Mostafa Ahmed Hammam, Moshira Mohamed Abdel Wahed

¹Department of Dermatology, Andrology and STDs Faculty of Medicine, Menoufiya University, Shibeen ElKoom, 32518, Egypt. olabakry8@gmail.com

Acta Dermatovenerologica Croatica : ADC

|September 5, 2013

Summary

Vitiligo patients show increased expression of p53 and Mdm2 proteins in both depigmented and normal skin. This suggests these proteins may protect vitiligo patients from sun damage and skin cancer.

Area of Science:

Dermatology
Oncology
Molecular Biology

Background:

Vitiligo is a common skin condition causing depigmentation, affecting 0.5% of the population.
Melanin protects skin from UV radiation, yet vitiligo patients rarely develop skin cancer despite DNA damage.
The protective mechanisms against actinic damage in vitiligo are not fully understood.

Purpose of the Study:

To investigate the role of p53 and Mdm2 proteins in protecting vitiligo patients from actinic damage and non-melanoma skin cancer.
To detect p53 and Mdm2 expression in depigmented and normally pigmented skin of vitiligo patients using immunohistochemistry.

Main Methods:

Immunohistochemical analysis of p53 and Mdm2 expression in skin biopsies.
Study included 34 vitiligo patients and 30 control subjects with outdoor occupations.

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Biopsies were taken from depigmented, normally pigmented, and healthy skin areas.

Main Results:

Strong expression of p53 and Mdm2 was observed in both depigmented and normally pigmented skin of vitiligo patients.
Expression was noted in the epidermis, skin adnexa, and blood vessels, differing significantly from controls.
Intense p53 and Mdm2 expression correlated with generalized vitiligo.

Conclusions:

Over-expression of p53 and Mdm2 in vitiligo skin may contribute to reduced actinic damage.
These proteins might play a role in the decreased incidence of non-melanoma skin cancer in vitiligo patients.