Related Experiment Video
Updated: Feb 10, 2026

Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
[Familial retinoblastoma: cytogenetic study of the tumor]
M Robledo Batanero1, A Manzanal Martínez, C Ayuso García
1Departamento de Genética, Fundación Jiménez Díaz, Madrid.
Abstract:
We report a case of familiar retinoblastoma, in which both mother and daughter show bilateral retinoblastoma. The cytogenetic study, in both peripheral blood lymphocytes and tumoral tissue did not show alterations on the 13 chromosome, although we found a complex kariotype in tumoral tissue defined by three celular lines. In all of them appears a marker in which the 6 chromosome is involved (der 6). The derivated of 6 chromosome are markers highly characteristic of the retinoblastoma cases, and can be related with the aggressivity of tumor and the appearance of the second tumors.
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