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Related Experiment Videos

Adrenal function in asthma.

K Priftis1, A D Milner, E Conway

  • 1Queen's Medical Centre, Nottingham.

Archives of Disease in Childhood
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

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Beclomethasone dipropionate in children with asthma can suppress cortisol excretion, especially at higher doses. Endocrine assessment is recommended if doses exceed 400 micrograms/m2/day.

Area of Science:

  • Pediatric Endocrinology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Inhaled corticosteroids (ICS) are a cornerstone of asthma management.
  • Potential endocrine side effects of ICS, such as growth impairment, are a concern.

Purpose of the Study:

  • To investigate the dose-dependent effects of beclomethasone dipropionate on cortisol and androgen excretion in children with asthma.
  • To explore the relationship between inhaled steroid use and potential endocrine disturbances contributing to growth delay.

Main Methods:

  • A study involving 25 children with asthma treated with beclomethasone dipropionate.
  • Measurement of daily cortisol excretion and cortisol metabolites.

Related Experiment Videos

  • Assessment of androgen excretion in relation to age and inhaled steroid dosage.

    • Main Results:

    • A dose-dependent suppression of daily cortisol excretion was observed with beclomethasone dipropionate.
    • Cortisol metabolites were frequently below the normal range at beclomethasone doses exceeding 400 micrograms/m2/day.
    • Androgen excretion was below normal in asthmatic children aged 8-13 years, irrespective of inhaled steroid use, suggesting a potential link to growth delay.

    Conclusions:

    • Beclomethasone dipropionate can suppress cortisol excretion in a dose-dependent manner.
    • While side effects exist, they do not warrant discouraging beclomethasone use for asthma.
    • Endocrine assessment is advisable for children receiving beclomethasone doses above 400 micrograms/m2/day.