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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Related Experiment Video

Updated: May 8, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

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Published on: March 16, 2022

Acute limb ischemia in nonagenarians.

G Galzerano¹, G de Donato, F Setacci

¹Department of Medical, Surgical and Neurosciences Unit of Vascular and Endovascular Surgery University of Siena, Siena, Italy. galzerano.giuseppe@gmail.com

The Journal of Cardiovascular Surgery

|September 5, 2013

Summary

Early revascularization for acute limb ischemia (ALI) in patients over 90 is safe and effective. Fogarty embolectomy demonstrates good outcomes, with low mortality and amputation rates in this elderly population.

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Methods for Acute and Subacute Murine Hindlimb Ischemia

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

Area of Science:

Vascular Surgery
Geriatric Medicine
Critical Care Medicine

Background:

Acute limb ischemia (ALI) carries significant risks of limb loss and mortality, particularly in elderly patients.
Outcomes for ALI are often worse in the geriatric population, necessitating specialized treatment strategies.

Purpose of the Study:

To evaluate the safety and efficacy of early revascularization in patients aged 90 years and older with ALI.
To quantify the outcomes of emergent surgical intervention for ALI in the very elderly.

Main Methods:

Prospective registry study conducted from January 2012 to January 2013.
Included 15 consecutive patients over 90 years old treated for ALI.
Utilized Duplex scan for preoperative assessment and Fogarty embolectomy, with optional endovascular completion.

Main Results:

18 revascularizations were performed in 15 patients, achieving 88.9% technical success.
One-year outcomes included 76.5% freedom from death, 88.2% freedom from amputation, and 71.3% freedom from re-occlusion.
In-hospital mortality was 5.9% and amputation rate was 6.2%.

Conclusions:

Patients over 90 present a significant challenge in vascular surgery due to high procedural risks.
Emergent revascularization using Fogarty Embolectomy for ALI is a safe and effective treatment option, even in the oldest patients.