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Updated: May 8, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Receptor tyrosine kinase-mediated angiogenesis
Michael Jeltsch1, Veli-Matti Leppänen, Pipsa Saharinen
1Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FIN-00014 Helsinki, Finland.
Cold Spring Harbor Perspectives in Biology
|September 5, 2013
Summary
The vascular endothelial growth factor (VEGF) and Tie receptor families are crucial for blood and lymphatic vessel development. Targeting these receptors offers therapeutic potential for diseases involving abnormal blood vessel growth (angiogenesis).
Area of Science:
- Endothelial biology
- Molecular and cellular biology
- Developmental biology
Background:
- Endothelial cells form the inner lining of blood and lymphatic vessels.
- Receptor tyrosine kinases (RTKs) like VEGFR and Tie are critical for vascular development.
- Dysregulated angiogenesis is implicated in numerous diseases.
Purpose of the Study:
- To review the VEGFR and Tie receptor families.
- To discuss their roles in developmental and pathological angiogenesis and lymphangiogenesis.
- To explore therapeutic strategies targeting these receptors.
Main Methods:
- Literature review of VEGFR and Tie receptor families.
- Analysis of their involvement in embryonic development and disease.
- Examination of therapeutic targeting approaches.
Main Results:
- VEGF and Tie receptors are endothelial cell-specific RTKs vital for vasculogenesis and lymphangiogenesis.
- These receptors are key regulators of both normal development and pathological angiogenesis.
- Targeting these pathways presents opportunities for therapeutic intervention.
Conclusions:
- VEGFR and Tie receptors are essential targets for modulating angiogenesis and lymphangiogenesis.
- Therapeutic strategies aim to block or enhance these pathways for disease treatment.
- Further research into these RTKs holds promise for novel therapies.
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