[Morpho-functional changes in the muscles of the limbs and their microcirculatory bed in acute ischemia]

On 26 mature dogs in a chronic experiment the character of compensatory-adaptive changes in muscles and their blood capillaries have been studied in dynamics of an acute ischemia of the extremity and at some stages of recirculation. After strangulation for two hours, thanks to joining in the compensatory-adaptive mechanisms, certain morphofunctional changes in the extremity tissues are revealed. As the duration of hypoxia increases (6-9 h), the destructive changes in the tissues become more severe. They are inherent in an acute hypoxia and accompanied with disaggregation and hydratation of cell membranes of endotheliocytes, with formation of vesicles and spherules, with increasing microclasmatosis, formation of myelin-like bodies, with destructive changes of organelles, with destruction of sarcoplasmic reticulum, with focal discoid necrosis, myocytolysis and sequestration of autolysis altered groups of muscle fibers. The data obtained serves as a base for elaboration of a pathogenically adequate surgical treatment of severe forms of an acute ischemia of extremities.