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Generalized dowling-degos disease: case reports
Jade Wititsuwannakul1, Nopadon Noppakun
1Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hosptial, Thai Red Cross Society, Bangkok, Thailand.
Annals of Dermatology
|September 5, 2013
Summary
Dowling-Degos disease (DDD) is a rare genetic disorder causing skin pigmentation changes and lesions. This study details generalized DDD cases, highlighting its varied presentation and diagnostic histopathology.
Area of Science:
- Dermatology
- Genetics
- Pathology
Background:
- Dowling-Degos disease (DDD) is a rare autosomal dominant skin condition.
- It typically presents with reticulate hyperpigmentation, comedones, and pitted scars.
Observation:
- This report describes generalized DDD in a family with autosomal dominant inheritance.
- Cases exhibited hypopigmented lesions rather than typical reticulate hyperpigmentation.
Findings:
- Histopathology is crucial for diagnosing DDD, revealing characteristic acanthosis with melanin at rete ridge tips.
- Generalized DDD can present with hypopigmentation, distinguishing it from other conditions like dermatopathia pigmentosa reticularis (DPR).
Implications:
- Understanding generalized DDD expands diagnostic possibilities for pigmentary disorders.
- Accurate histopathological differentiation is key for correct diagnosis and management of rare genetic skin diseases.
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