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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Microscopic Colitis is Associated with Several Concomitant Diseases.

Bodil Roth1, Jonas Manjer, Bodil Ohlsson

  • 1Department of Clinical Sciences, Section of Internal Medicine, Skåne University Hospital, Lund University, Sweden.

Drug Target Insights
|September 5, 2013
PubMed
Summary
This summary is machine-generated.

Microscopic colitis (MC) patients show higher rates of various conditions, including autoimmune diseases, hypertension, and respiratory issues. Smoking is also more common in individuals with this inflammatory bowel disease.

Keywords:
concomitant diseasesdrug treatmentsmicroscopic colitiswomen

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Area of Science:

  • Gastroenterology
  • Epidemiology

Background:

  • Microscopic colitis (MC) is characterized by intestinal inflammation and diarrhea, primarily affecting middle-aged women.
  • The exact cause of MC remains unknown, but associations with autoimmune conditions have been noted, though not rigorously compared to controls.

Purpose of the Study:

  • To investigate the prevalence of common diseases in patients diagnosed with microscopic colitis compared to a general population control group.

Main Methods:

  • Retrospective analysis of patient data.
  • Comparison of disease prevalence between microscopic colitis patients and control subjects from the general population.

Main Results:

  • Microscopic colitis patients exhibited a higher prevalence of hypertension, rheumatoid arthritis, asthma/bronchitis, ischemia, and diabetes mellitus compared to controls.
  • No significant difference in the prevalence of gastric ulcer or cancer was observed between the groups.
  • MC patients were more frequently former or current smokers (72.5%) than controls (57.7%).

Conclusions:

  • Microscopic colitis patients present with an increased prevalence of several comorbidities, extending beyond autoimmune disorders.
  • These findings highlight the need to consider a broader spectrum of associated conditions in MC management.