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Updated: May 8, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Spontaneous conversion of atrial fibrillation to normal sinus rhythm following recurrent cerebral infarctions
Kyungmi Oh1, Jeong-Yoon Choi, Byung-Jo Kim
1Department of Neurology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Insights
This case study reports a rare instance of atrial fibrillation spontaneously converting to normal sinus rhythm following a stroke. This finding suggests a potential link between brain function and cardiac rhythm control.
Area of Science:
- Neurology
- Cardiology
- Neuroscience
Background:
- Atrial fibrillation is commonly observed post-stroke, particularly with right insular infarcts, suggesting a cerebrogenic influence on cardiac rhythm.
- The spontaneous conversion of atrial fibrillation to normal sinus rhythm after a stroke has not been previously documented.
Observation:
- An 88-year-old male with untreated atrial fibrillation was hospitalized for a left middle cerebral artery territory infarction.
- During hospitalization, a second ischemic event occurred in the right middle cerebral artery territory.
- Concurrently, the patient's atrial fibrillation spontaneously converted to a normal sinus rhythm.
Findings:
- The restored sinus rhythm persisted until the patient's death from sepsis.
- This case provides evidence supporting the theory of brain involvement in cardiac rhythm regulation.
Implications:
- Physicians should consider the possibility of atrial fibrillation transforming to normal sinus rhythm post-stroke, especially when no other risk factors are identified in acute cerebral infarction cases with suspected cardioembolism.
- This phenomenon highlights the intricate relationship between the brain and the heart's electrical activity.
Abstract:
Post-stroke atrial fibrillation has been frequently reported especially in the patients with right insular infarct as an evidence of cerebrogenic mechanism affecting on cardiac rhythm. However, conversion to normal sinus rhythm after stroke in patients who had atrial fibrillation has not been reported. A 88-year-old men who had untreated atrial fibrillation was admitted to hospital due to left middle cerebral artery territory infarction. During admission, second ischemic attack occurred in right middle cerebral artery territory. At that time, his atrial fibrillation converted spontaneously to normal sinus rhythm. Restored sinus rhythm sustained until he died due to sepsis. This case is evidence supporting a theory that brain is associated with control of cardiac rhythm. If no risk factor is revealed by intensive investigation in patients with acute cerebral infarctions that cardioembolism is strongly suspected as a cause, physicians should concern transformation of atrial fibrillation to normal sinus rhythm after stroke.
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