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Updated: May 8, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

Bioenergetic medicine.

Russell H Swerdlow¹

¹Departments of Neurology, Molecular and Integrative Physiology, Biochemistry and Molecular Biology, University of Kansas School of Medicine, Kansas City, KS, USA; Alzheimer's Disease Center, University of Kansas Medical Center, Fairway, KS, USA.

British Journal of Pharmacology

|September 6, 2013

Summary

This summary is machine-generated.

Bioenergetic medicine manipulates biological energy flow to improve health. This therapeutic strategy shows promise for treating cancers and neurodegenerative diseases by targeting metabolic pathways.

Keywords:

Alzheimer's disease cancer glycolysis law of mass action mitochondria neurodegeneration

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Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

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Area of Science:

Biochemistry
Metabolic pathways
Therapeutic strategies

Background:

Bioenergetic medicine is a therapeutic strategy focused on manipulating bioenergetic fluxes for health benefits.
This approach utilizes the law of mass action, influencing systems that monitor and respond to altered biological energy flow.

Purpose of the Study:

To discuss the therapeutic strategy of bioenergetic medicine.
To highlight its potential applications in treating diseases like cancer and neurodegenerative conditions.

Main Methods:

Manipulation of bioenergetic fluxes.
Application of the law of mass action.
Targeting intersecting and intertwined energy metabolism pathways.

Main Results:

Interventions in bioenergetic medicine can predictably alter multiple metabolic fluxes.
Existing bioenergetic medicine interventions are feasible for certain diseases.
New therapeutic approaches are emerging for neurodegenerative conditions and cancers.

Conclusions:

Bioenergetic medicine offers a novel therapeutic avenue.
The predictable indirect effects of targeting metabolic fluxes can be therapeutically beneficial.
This strategy is transitioning from research to clinical application for complex diseases.