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Updated: May 8, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Better performance of CARs deprived of the PD-1 brake
Aizea Morales-Kastresana1, Sara Labiano, José I Quetglas
1Authors' Affiliation: Center for Applied Medical Research, CIMA and University Clinic, University of Navarra, Pamplona, Spain.
Abstract:
Immunotherapies often permit combinations to increase efficacy. Two approaches are currently leading our field: adoptive therapy with T cells transfected with chimeric antigen receptors and monoclonal antibodies blocking the PD-1/PD-L1 (B7-H1) axis. In this issue of Clinical Cancer Research, preclinical evidence for a synergistic combination of such approaches is reported.
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