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Regional lung ventilation in humans during hypergravity studied with quantitative SPECT.

M Ax¹, L L Karlsson, A Sanchez-Crespo

¹Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden; Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Respiratory Physiology & Neurobiology

|September 6, 2013

Summary

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Hypergravity causes arterial desaturation by shifting regional lung ventilation to non-dependent areas. This study provides the first high-resolution measurements of human ventilation under hypergravity conditions.

Area of Science:

Physiology
Aerospace Medicine
Respiratory System

Background:

Arterial desaturation during hypergravity was previously attributed to blood flow redistribution to dependent lung regions.
Recent findings challenged this view, suggesting paradoxical blood flow redistribution to non-dependent lung regions.

Purpose of the Study:

To quantify regional lung ventilation in healthy volunteers under normal (1G) and hypergravity (3G) conditions.
To investigate the role of regional ventilation changes in arterial desaturation during hypergravity.

Main Methods:

10 healthy supine volunteers participated.
Regional ventilation was measured using Technegas ((99m)Tc) and quantitative single photon emission computed tomography (SPECT).
Measurements were taken at 1G and 3G.

Keywords:

Human centrifuge Technegas Technetium Ventilation-to-perfusion mismatch

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Main Results:

Hypergravity (3G) induced significant arterial desaturation (mean decrease of 8%).
A significant shift in regional ventilation from dependent to non-dependent lung regions was observed under 3G (ratio increased from 0.81±0.12 at 1G to 1.63±0.35 at 3G).
This ventilation redistribution was quantitatively different from blood flow redistribution patterns.

Conclusions:

Arterial desaturation during hypergravity is likely caused by quantitatively different redistributions of blood flow and ventilation.
This study presents the first high-resolution measurements of regional ventilation in humans under normal breathing during hypergravity.