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Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: May 8, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Lower extremity amputations: factors associated with mortality or contralateral amputation.

Samir K Shah1, James F Bena, Matthew T Allemang

  • 11Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Vascular and Endovascular Surgery
|September 6, 2013
PubMed
Summary

Patients with peripheral artery disease (PAD) requiring lower extremity amputation face high mortality and contralateral amputation risks. Elderly patients on dialysis are especially vulnerable, highlighting the need for limb preservation strategies.

Keywords:
contralateral amputationmajor amputationmortality

Related Experiment Videos

Last Updated: May 8, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Area of Science:

  • Vascular Surgery
  • Amputation Outcomes
  • Peripheral Artery Disease Research

Background:

  • Lower extremity amputation due to peripheral artery disease (PAD) is associated with significant mortality.
  • Contralateral limb amputation is a risk following major lower extremity amputation.

Purpose of the Study:

  • To identify patient variables associated with mortality after lower extremity amputation.
  • To identify patient variables associated with contralateral amputation.

Main Methods:

  • Retrospective review of 454 major lower extremity amputations in 391 patients with PAD (2004-2009).
  • Kaplan-Meier survival estimates and Cox proportional hazard models were used.
  • Multivariate analysis identified independent predictors of mortality and contralateral amputation.

Main Results:

  • High rates of comorbidities including diabetes (63%), hypertension (83%), and renal insufficiency (35%).
  • Perioperative mortality was 9.2%; 12-month and 24-month survival rates were 70% and 60%, respectively.
  • Independent risk factors for mortality included COPD, dialysis dependence, high cardiac risk, and guillotine amputation. Dialysis and higher-level revision were associated with contralateral amputation.

Conclusions:

  • Patients with advanced PAD requiring amputation have poor survival and high rates of contralateral amputation.
  • Elderly patients on dialysis are at particularly high risk for adverse outcomes post-amputation.
  • Strategies for limb preservation and comorbidity optimization are crucial for this patient population.