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Related Experiment Video

Updated: May 8, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

A broader view of perirhinal function: from recognition memory to fluency-based decisions.

Ilana T Z Dew¹, Roberto Cabeza

¹Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA. ilana.dew@duke.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|September 6, 2013

Summary

The perirhinal cortex (PRC) may process memory fluency, not just long-term memory retrieval. Reduced PRC activity for familiar items might reflect easier processing, influencing recognition memory.

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Area of Science:

Neuroscience
Cognitive Psychology
Neuroimaging

Background:

The perirhinal cortex (PRC) is crucial for recognition memory.
Its reduced activity for familiar items is often linked to long-term memory (LTM) retrieval.
However, this reduction might also reflect enhanced processing fluency.

Purpose of the Study:

To investigate whether the PRC's role in recognition memory is related to processing fluency rather than solely LTM retrieval.
To differentiate the contributions of fluency and LTM retrieval to PRC activity.

Main Methods:

Human fMRI study utilizing the masked priming paradigm to manipulate processing fluency.
Participants performed an old-new recognition test with subliminally presented primes.
Behavioral responses and fMRI data were analyzed to assess PRC activity and connectivity.

Main Results:

Masked priming increased "oldness" responses to both old and new items, indicating a fluency effect.
For new items, priming reduced PRC activity, predicting misattribution of fluency to oldness.
PRC activity for old items also reflected fluency, and its connectivity modulated with other brain regions.

Conclusions:

The PRC's function in recognition memory may be broader than just LTM retrieval, encompassing the processing of perceptual fluency.
Fluency influences PRC activity and its interactions with other brain regions involved in memory.
These findings challenge traditional views of the PRC's specific role in memory recall.