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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 8, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

CT interpretation by ASPECTS in hyperacute ischemic stroke predicting functional outcomes.

Warinthorn Phuttharak1, Kittisak Sawanyawisuth, Boonrerk Sangpetngam

  • 1Diagnostic Radiological Unit, Department of Radiology, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, 40002, Thailand.

Japanese Journal of Radiology
|September 6, 2013
PubMed
Summary

The Alberta Stroke Program Early CT Scores (ASPECTS) effectively predict functional outcomes in acute stroke patients treated with recombinant tissue-type plasminogen activator (rt-PA). This score is a significant factor for determining patient status at 3 months post-treatment.

Related Experiment Videos

Last Updated: May 8, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Area of Science:

  • Neurology
  • Radiology
  • Emergency Medicine

Background:

  • Hyperacute stroke management requires timely and accurate prognostic tools.
  • Recombinant tissue-type plasminogen activator (rt-PA) is a critical treatment for acute ischemic stroke.
  • Predicting post-treatment outcomes aids in patient management and resource allocation.

Purpose of the Study:

  • To evaluate the predictive value of the Alberta Stroke Program Early CT Scores (ASPECTS) for functional outcomes.
  • To assess the correlation between ASPECTS and modified Rankin Scale scores at 3 months post-rt-PA treatment.
  • To determine if ASPECTS can guide treatment decisions in hyperacute stroke patients within the 4.5-hour window.

Main Methods:

  • A cohort of 162 hyperacute stroke patients receiving rt-PA within 4.5 hours was analyzed.
  • Alberta Stroke Program Early CT Scores (ASPECTS) were systematically calculated for each patient.
  • Functional status at 3 months was assessed using the modified Rankin Scale (mRS).

Main Results:

  • Baseline ASPECTS and NIHSS scores were significant predictors of functional status (dependent or death) at 3 months.
  • Time to CT scan or rt-PA administration did not show a significant association with functional outcomes.
  • 116 patients (71.60%) achieved an independent functional status at 3-month follow-up.

Conclusions:

  • The ASPECTS is a valuable tool for predicting functional outcomes in acute stroke patients treated with rt-PA within the 4.5-hour window.
  • ASPECTS can assist clinicians in prognostication and potentially in treatment planning for stroke patients.
  • Early CT assessment using ASPECTS provides crucial prognostic information beyond treatment timing alone.