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Updated: May 8, 2026
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
A new structure of a serotonin salt: comparison and conformational analysis of all known serotonin complexes
Denis Rychkov1, Elena V Boldyreva, Nikolay A Tumanov
1REC-008, Novosibirsk State University, Pirogova 2, Novosibirsk 630090, Russian Federation. rychkov.dennis@gmail.com
Abstract:
Four serotonin salt structures (serotonin adipate, C10H13N2O(+)·C6H9O4(-), is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.
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