Related Experiment Video
Updated: May 8, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk
1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Połabska 4, 70-115, Szczecin, Poland, debniak@pum.edu.pl.
Archives of Dermatological Research
|September 6, 2013
Summary
Genetic variants in the TRAF3IP2 gene are associated with psoriasis vulgaris, particularly pustular psoriasis. No significant links were found for RPTOR or ZNF750 genes in this study.
Area of Science:
- Genetics
- Dermatology
- Immunology
Background:
- Psoriasis vulgaris is a complex genetic disorder with an incompletely understood molecular basis.
- Identifying genetic susceptibility factors is crucial for understanding disease pathogenesis and developing targeted therapies.
Purpose of the Study:
- To investigate the association between common variants in ZNF750, RPTOR, and TRAF3IP2 genes and psoriasis vulgaris.
- To explore the relationship between these genetic variants and specific clinical phenotypes of psoriasis.
Main Methods:
- Genotyping of 10 common variants in ZNF750, RPTOR, and TRAF3IP2 genes using Taqman assays and sequencing.
- Analysis of a cohort comprising 1,034 case-control individuals.
- Statistical analysis to assess associations between genetic variants, psoriasis susceptibility, and clinical phenotypes.
Main Results:
- Significant association found between TRAF3IP2 variants, particularly rs33980500, and psoriasis susceptibility (OR=2.5, p=0.01790).
- Replication of the association of TRAF3IP2 rs33980500 with psoriasis risk.
- New associations identified between TRAF3IP2 variants and pustular psoriasis, disease severity, age of onset, and familial aggregation.
Conclusions:
- The TRAF3IP2 gene, specifically the rs33980500 variant, is confirmed as a susceptibility factor for psoriasis vulgaris.
- Genetic variations in TRAF3IP2 are linked to distinct clinical presentations, including pustular psoriasis and disease severity.
- No significant associations were observed for RPTOR and ZNF750 gene variants with psoriasis or its phenotypes in this cohort.
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