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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
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Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

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Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
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Quantitative lung perfusion evaluation using Fourier decomposition perfusion MRI.

Åsmund Kjørstad1, Dominique M R Corteville, Andre Fischer

  • 1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Germany.

Magnetic Resonance in Medicine
|September 6, 2013
PubMed
Summary

Quantitative lung perfusion MRI is now possible using Fourier Decomposition (FD) with postprocessing. This method provides accurate, comparable pulmonary blood flow (PBF) values, improving clinical assessments.

Keywords:
ASLFourier decompositionnoncontrast enhanced lung MRIperfusion imagingquantification

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Area of Science:

  • Medical Imaging
  • Cardiovascular and Respiratory Systems

Background:

  • Fourier Decomposition (FD) MRI offers noninvasive lung ventilation and perfusion data.
  • Current FD perfusion maps lack quantitative values, hindering clinical follow-ups and comparisons.

Purpose of the Study:

  • To develop a quantitative approach for lung perfusion using FD MRI.
  • To obtain physically meaningful and quantifiable perfusion maps.

Main Methods:

  • Quantified FD perfusion images by comparing lung parenchyma pixels to aorta blood-filled pixels.
  • Combined pixel blood percentage with temporal data for quantitative blood flow values.
  • Validated results against SEEPAGE measurements in 10 healthy volunteers.

Main Results:

  • Pulmonary blood flow (PBF) values obtained were within expected ranges.
  • FD and SEEPAGE methods showed good agreement (mean difference 0.2 mL/min/100 mL).
  • Bland-Altman analysis indicated no systematic bias between the two methods.

Conclusions:

  • Fourier Decomposition MRI, with postprocessing, enables quantitative lung perfusion assessment.
  • This advancement facilitates more precise patient monitoring and inter-patient comparisons.