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Alteration of vascular function is an important factor in the correlation between visit-to-visit blood pressure

Tatsuo Kawai1, Mitsuru Ohishi, Norihisa Ito

  • 1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Journal of Hypertension
|September 6, 2013
PubMed

Insights

High blood pressure variability is linked to artery hardening and worse outcomes. This study shows visit-to-visit systolic blood pressure (SBP) variability predicts cardiovascular disease and mortality.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Atherosclerosis Studies

Background:

  • Visit-to-visit systolic blood pressure (SBP) variability is associated with cardiovascular events.
  • The precise mechanisms linking SBP variability to patient prognosis remain unclear.

Purpose of the Study:

  • To investigate the correlation between visit-to-visit SBP variability and systemic atherosclerotic changes.
  • To assess the relationship between SBP variability and the prognosis of cardiovascular disease (CVD) and overall mortality.

Main Methods:

  • Analysis of 485 patients with essential hypertension from the NOAH study cohort.
  • Correlation analysis of SBP variability with clinical parameters, CVD incidence, and total mortality.
  • Prospective examination using Kaplan-Meier analysis and hazard ratio adjustments.

Main Results:

  • Higher SBP variability correlated with increased statin use, pulse wave velocity (PWV), left-ventricular mass index (LVMI), plaque score, and carotid artery resistive index.
  • Patients with higher SBP variability showed a lower estimated glomerular filtration rate.
  • Higher SBP variability was significantly associated with increased CVD incidence and mortality rates, remaining an independent risk factor for mortality.

Conclusions:

  • Visit-to-visit SBP variability is significantly associated with systemic atherosclerotic changes, CVD incidence, and mortality.
  • Macrovascular atherosclerosis and altered arterial functions contribute to the link between SBP variability and CVD incidence.
Abstract

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