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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: May 8, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

[Chronic inflammation and AA amyloidosis].

N Blank1, S O Schönland

  • 1Universitätsklinikum Heidelberg, Medizinische Klinik 5, Sektion Rheumatologie und Amyloidosezentrum, Heidelberg.

Deutsche Medizinische Wochenschrift (1946)
|September 6, 2013
PubMed
Summary

Systemic AA amyloidosis, a complication of inflammatory diseases, primarily affects the kidneys. Early screening for microalbuminuria and controlling the acute phase reaction are crucial for managing renal function and patient outcomes.

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Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Context:

  • Systemic AA amyloidosis is a serious complication linked to chronic inflammatory conditions.
  • Kidney involvement is the most common manifestation of this condition.
  • Microalbuminuria screening is recommended for at-risk individuals.

Purpose:

  • To outline the management strategies for systemic AA amyloidosis with a focus on renal preservation.
  • To emphasize the importance of controlling the underlying inflammatory process.
  • To discuss therapeutic options including supportive care and transplantation.

Summary:

  • Effective control of the acute phase reaction is the primary therapeutic goal.
  • Maintaining controlled blood pressure and employing nephroprotective treatments are vital for renal function.
  • Dialysis may be necessary for progressive amyloidosis, while renal transplantation is an option if the primary disease is well-managed.

Impact:

  • Highlights the critical role of early detection and management in preventing severe renal damage.
  • Provides a framework for optimizing patient care and long-term renal outcomes in AA amyloidosis.
  • Underscores the multidisciplinary approach required for managing this complex condition.