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Updated: May 8, 2026

05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Picture perfect: DNA-templated photoaffinity labeling
Sofia Barluenga1, Nicolas Winssinger
1Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva (Switzerland).
Chembiochem : a European Journal of Chemical Biology
|September 6, 2013
Abstract:
Just so far apart and no further: Small molecules target ID by DNA tagging. Nucleic acid hybridization has been used to pair a photo-crosslinking group with a small molecule of interest. Following photoactivation, the protein(s) interacting with the small molecule are covalently linked to a nucleic acid tag.

