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Children with chronic renal failure in Sweden 1978-1985
E Esbjörner1, S Aronson, U Berg
1Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
Insights
This study tracked chronic renal failure (CRF) in Swedish children from 1978-1985. Prevalence of CRF and terminal renal failure (TRF) increased significantly during this period.
Area of Science:
- Pediatric Nephrology
- Epidemiology of Kidney Disease
Background:
- Chronic renal failure (CRF) poses a significant health challenge in pediatric populations.
- Understanding the epidemiological trends of CRF is crucial for public health planning.
Purpose of the Study:
- To determine the incidence and prevalence of chronic renal failure (CRF) in Swedish children between 1978 and 1985.
- To identify the primary causes of renal failure in this pediatric cohort.
Main Methods:
- A nationwide survey of pediatric chronic renal failure (CRF) in Sweden.
- Utilized age-related creatinine cut-off levels to define glomerular filtration rate (GFR) < 30 ml/min/1.73 m2.
- Data collected for the period 1978-1985.
Main Results:
- Mean annual incidence of CRF was 6.9/million children; terminal renal failure (TRF) was 4.4/million children.
- Prevalence of preterminal renal failure increased from 14.1 to 26.1 per million children (1978-1985).
- Prevalence of TRF increased from 12.4 to 16 per million children (1978-1985).
- Leading causes of renal disease: malformations (42%), hereditary disorders (27%), glomerular diseases (14%).
Conclusions:
- The incidence and prevalence of pediatric CRF and TRF in Sweden showed an increasing trend during 1978-1985.
- Congenital malformations and hereditary disorders are the predominant causes of CRF in children.
- Pyelonephritis with vesico-ureteral reflux was a less common cause of renal failure in this cohort.
Abstract:
A survey of chronic renal failure (CRF) in Swedish children was carried out for the period 1978-1985, using age-related cut-off levels for creatinine concentrations corresponding approximately to a glomerular filtration rate of 30 ml/min per 1.73 m2. The mean annual incidence of CRF was 6.9 and of terminal renal failure (TRF) 4.4/million children. The prevalence increased during the study period, for preterminal renal failure from 14.1 (1978) to 26.1 (1985) and for TRF from 12.4 to 16/million children. The main groups of primary renal disease were malformations (42%), hereditary disorders (27%), and glomerular diseases (14%), while pyelonephritis with vesico-ureteral reflux only made up 5%.