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Updated: May 8, 2026
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Pattern Generation for Micropattern Traction Microscopy
Published on: February 17, 2022
A humidity-sensitive hydrogel-Bacillus spore composite for micropatterning of biomolecular gradients
Richard L Gieseck1, Bin-Da Chan, Cagri A Savran
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
The Review of Scientific Instruments
|September 7, 2013
Abstract:
A composite material consisting of Bacillus subtilis spores suspended in a humidity sensitive hydrogel can be used to pattern biomolecules in different concentrations directly onto glass surfaces using a mechanical micromanipulator. By altering the relative humidity surrounding the composite gel during deposition, surface concentration of patterned biomolecules can be controlled and varied to create user-defined, biomolecular surface concentrations.
