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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Fecal bacteriotherapy in the treatment of Clostridium difficile infection.

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[Fecal bacteriotherapy for the treatment of recurrent Clostridium difficile colitis used in the Clinic of Infectious Diseases of the University Hospital Brno in 2010-2014 - a prospective study].

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Updated: May 8, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

[Colitis precipitated by Clostridium difficile -  a serious current problem].

P Husa1

  • 1Klinika infekcnich chorob Lekarske fakulty MU a FN Brno. phusa@fnbrno.cz

Vnitrni Lekarstvi
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

Clostridium difficile infection (CDI) is a major hospital-acquired infection risk. Limiting CDI requires careful antibiotic selection, especially avoiding high-risk antibiotics when possible to prevent patient colonization.

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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

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Last Updated: May 8, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Stewardship

Background:

  • Clostridium difficile is a significant cause of hospital-acquired infections.
  • Patient colonization risk increases with hospital stay duration and local epidemiology.
  • Interdisciplinary collaboration is crucial for managing this serious disease.

Purpose of the Study:

  • To highlight the importance of rational antibiotic therapy in preventing Clostridium difficile infections.
  • To emphasize the risks associated with certain antibiotics in contaminated environments.
  • To advocate for the use of lower-risk antibiotics when feasible.

Main Methods:

  • Review of existing literature on Clostridium difficile epidemiology and infection control.
  • Analysis of antibiotic usage patterns and their correlation with infection rates.
  • Emphasis on clinical decision-making regarding antibiotic selection.

Main Results:

  • Hospitalized patients face an increasing risk of Clostridium difficile colonization.
  • Antibiotic administration, even when indicated, can be dangerous in contaminated settings.
  • High-risk antibiotics (aminopenicillins, fluoroquinolones, cefalosporins) pose a significant threat.

Conclusions:

  • Rational antibiotic therapy is fundamental to controlling Clostridium difficile infections.
  • Avoiding high-risk antibiotics in favor of lower-risk alternatives is essential.
  • Effective management necessitates a comprehensive, interdisciplinary approach to infection control.