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Genetics, structure, function, mode of actions and role in cancer development of CYP17

Tatyana A Sushko, Andrei A Gilep, Sergey A Usanov1

  • 1Institute of Bioorganic Chemistry NASB Belarus, 220141 Minsk, Kuprevicha str. 5/2, Belarus. agilep@iboch.bas-net.by.

Anti-Cancer Agents in Medicinal Chemistry
|September 7, 2013
PubMed

Insights

Steroid 17α-hydroxylase/17,20-lyase (CYP17) inhibition treats hormone-dependent cancers. This review analyzes CYP17 genetics, structure, specificity, and inhibitors for cancer therapy.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Oncology

Background:

  • Prostate and breast cancers are often hormone-dependent.
  • Inhibiting steroid 17α-hydroxylase/17,20-lyase (CYP17) is a key treatment for androgen-dependent prostate cancer.
  • CYP17 is essential for steroid hormone biosynthesis, directing pathways towards corticosteroids or sex hormones.

Purpose of the Study:

  • To review current knowledge on CYP17.
  • To analyze the genetics, molecular structure, substrate specificity, and inhibitors of CYP17.

Main Methods:

  • Literature review of scientific articles on CYP17.
  • Analysis of existing data on CYP17 genetics and structure.
  • Discussion of substrate specificity and known inhibitors.

Main Results:

  • CYP17 possesses dual enzymatic activities: 17alpha-hydroxylase and 17,20-lyase.
  • The enzyme's activity dictates the production of either corticosteroids or sex hormones.
  • Information on CYP17 genetics, structure, substrate interactions, and inhibition is synthesized.

Conclusions:

  • Understanding CYP17's role and characteristics is vital for developing targeted cancer therapies.
  • Further research into CYP17 inhibitors could lead to improved treatments for hormone-dependent cancers.

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