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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology.

Conor Mc Guire1, Marco Prinz, Rudi Beyaert

  • 1Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

Trends in Molecular Medicine
|September 7, 2013
PubMed
Summary

Nuclear factor kappa B (NF-κB) signaling is crucial in autoimmune demyelinating diseases like multiple sclerosis (MS). This review clarifies NF-κB

Keywords:
NF-κBTh17cuprizonedemyelinationexperimental autoimmune encephalomyelitismultiple sclerosis

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Area of Science:

  • Neuroimmunology
  • Molecular Biology
  • Inflammation Research

Background:

  • Nuclear factor kappa B (NF-κB) signaling regulates immune and inflammatory responses.
  • NF-κB is implicated in the pathogenesis of autoimmune demyelinating diseases, including multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
  • NF-κB is vital for peripheral immune cell activation and central nervous system (CNS) pathology during disease development.

Purpose of the Study:

  • To review recent evidence on the role of NF-κB in various cell compartments contributing to MS pathology.
  • To explore the implications of NF-κB's role for developing therapeutic strategies for MS and other CNS demyelinating diseases.

Main Methods:

  • Literature review of recent scientific evidence.
  • Analysis of NF-κB's function in different cell types within the CNS.
  • Examination of therapeutic strategies targeting NF-κB in demyelinating diseases.

Main Results:

  • NF-κB plays critical roles in both peripheral immune cells and resident CNS cells during autoimmune demyelination.
  • Understanding cell-specific functions of NF-κB is key to developing targeted therapies.
  • NF-κB signaling pathways are central to the inflammatory processes driving MS and EAE.

Conclusions:

  • NF-κB is a significant factor in the development and progression of MS and other demyelinating conditions.
  • Targeting NF-κB signaling in specific cell compartments offers potential therapeutic avenues for CNS demyelinating diseases.
  • Further research into cell-specific NF-κB functions can refine treatment strategies for MS.