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Preterm infants have altered adiponectin levels at term-equivalent age even if they do not present with extrauterine

Yuya Nakano1, Kazuo Itabashi, Motoichiro Sakurai

  • 1Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Hormone Research in Paediatrics
|September 7, 2013
PubMed

Insights

Preterm infants show altered adiponectin levels by term-equivalent age. Postnatal growth influences total adiponectin (T-Ad) and high-molecular-weight adiponectin (HMW-Ad) increases, while HMW% may be predetermined.

Area of Science:

  • Neonatal research
  • Endocrinology
  • Growth and development

Background:

  • Adiponectin, a key metabolic hormone, plays a role in infant development.
  • Understanding adiponectin profiles in preterm infants is crucial for assessing long-term health outcomes.

Purpose of the Study:

  • To determine total adiponectin (T-Ad) and high-molecular-weight adiponectin (HMW-Ad) levels in preterm infants at term-equivalent age.
  • To explore the relationship between adiponectin levels and early postnatal growth in this population.

Main Methods:

  • Compared adiponectin levels in 58 preterm infants (born ≤34 weeks gestation) and 43 term infants.
  • Measured T-Ad and HMW-Ad at birth and term-equivalent age in preterm infants, and at birth in term infants.
  • Assessed associations between postnatal weight changes and adiponectin levels.

Main Results:

  • Preterm infants had higher T-Ad and lower HMW-Ad to T-Ad ratio (HMW%) at term-equivalent age compared to term infants.
  • Positive associations were found between body weight SD score changes and increases in T-Ad and HMW-Ad from birth to term-equivalent age.
  • HMW% changes showed a negative association only with cord blood HMW%.

Conclusions:

  • Preterm infants exhibit distinct adiponectin profiles at term-equivalent age.
  • Postnatal growth appears to drive adiponectin increases in preterm infants.
  • HMW% regulation may occur prenatally and persist until term-equivalent age.
Abstract

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