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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Published on: September 27, 2024

[Synchronous multiple primary lung and colon cancers].

Sumitaka Yamanaka1, Atsuhiko Sakamoto, Hiroshi Tomoyasu

  • 1Department of Thoracic Surgery, Omori Red Cross Hospital, Tokyo, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

This rare surgical case details a 74-year-old woman with synchronous multiple primary lung cancers and colon cancers. Both conditions were successfully treated with surgical resection and endoscopic procedures.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Gastroenterology

Background:

  • Synchronous multiple primary cancers are rare, presenting diagnostic and therapeutic challenges.
  • Early detection of lung nodules and colon polyps is crucial for patient outcomes.

Observation:

  • A 74-year-old woman presented with incidentally detected abnormal chest shadows.
  • Chest computed tomography (CT) revealed two right lung nodules; transbronchial lung biopsy (TBLB) confirmed adenocarcinoma in the middle lobe.
  • Positron emission tomography (PET) indicated colon cancer, with colonoscopy revealing multiple polyps and cancers.

Findings:

  • Immunostaining (thyroid transcription factor-1 and Napsin-A) aided in distinguishing primary origins.
  • Pathological diagnosis confirmed synchronous multiple primary lung cancers: adenocarcinoma and squamous cell carcinoma.
  • The patient underwent right upper and middle lobectomy with lymph node dissection for lung cancers, followed by endoscopic mucosal resection and left hemicolectomy for colon cancers.

Implications:

  • This case highlights the importance of comprehensive staging and diagnostic workup for patients with multiple suspicious findings.
  • Successful surgical and endoscopic management of synchronous multiple primary lung and colon cancers is feasible.
  • Further research into the genetic and environmental factors contributing to synchronous multiple primary malignancies is warranted.