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Updated: May 8, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
Structure homology and interaction redundancy for discovering virus-host protein interactions
Benoît de Chassey1, Laurène Meyniel-Schicklin, Anne Aublin-Gex
1Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Laboratoire de virologie, 103 grande rue de la Croix-Rousse, Lyon, F-69004, France.
Abstract:
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
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