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miRNA expression correlated with morphological findings in chronic myeloid leukemia treated with imatinib mesylate

Niklas Gebauer1, Veronica Bernard, Wolfgang Gebauer

  • 1Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.

Acta Haematologica
|September 7, 2013
PubMed
Abstract

No abstract available in PubMed .

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...