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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Electronic health record design and implementation for pharmacogenomics: a local perspective
Josh F Peterson1, Erica Bowton, Julie R Field
11] Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA; [2] Division of General Internal Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA;
Summary
Implementing electronic health records for pharmacogenomics is key for integrating genomic medicine. This study details a system design for actionable clinical decision support from genetic data.
Area of Science:
- Genomic Medicine
- Clinical Informatics
- Pharmacogenomics
Background:
- Integrating genomic medicine into clinical practice requires robust electronic health record (EHR) systems.
- Few published guides exist for implementing genomic services within healthcare settings.
Purpose of the Study:
- To describe the design, features, and evolution of a custom EHR system supporting a pharmacogenomics program.
- To address the challenge of translating genomic data into clinically actionable information within an EHR.
Main Methods:
- Tracked the 4-year development of a locally developed EHR for a pharmacogenomics program at an academic medical center.
- Implemented mechanisms for preemptive and reactive pharmacogenomics panel ordering.
- Developed a service to translate genotype to drug-response phenotype and integrate alerts into the EHR.
Main Results:
- EHR mechanisms enabled preemptive genotyping and ordering based on drug indication.
- Genetic data were selectively released based on clinical actionability and evidentiary standards.
- The system provided clinical decision support, updated records, and generated patient-accessible genomic results.
Conclusions:
- The developed EHR design for pharmacogenomics has broad applicability.
- Challenges in representing genomic data for clinical actionability and model scalability were discussed.
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