Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids.

Nature communications·2026
Same author

[Development and validation of a questionnaire assessing physiotherapists' knowledge, attitudes, and practices regarding falls among older adults].

Orvosi hetilap·2026
Same author

Axolotls retain fertility throughout lifespan.

BMC biology·2026
Same author

Divergent stem cell mechanisms govern the primary body axis and appendage regeneration in the axolotl.

Science advances·2026
Same author

A Robust and Reproducible Protocol for Neural Tube Organoid Generation from Single Mouse Embryonic Stem Cells.

Journal of visualized experiments : JoVE·2026
Same author

Innovations in spinal cord cell type heterogeneity across vertebrate evolution.

bioRxiv : the preprint server for biology·2025
Same journal

Zebrafish models of acute leukemias: Current models and future directions.

Wiley interdisciplinary reviews. Developmental biology·2020
Same journal

Schwann cell development: From neural crest to myelin sheath.

Wiley interdisciplinary reviews. Developmental biology·2020
Same journal

Human pluripotent stem cell-derived lung organoids: Potential applications in development and disease modeling.

Wiley interdisciplinary reviews. Developmental biology·2020
Same journal

The macro and micro of chromosome conformation capture.

Wiley interdisciplinary reviews. Developmental biology·2020
Same journal

Single-cell RNA sequencing in Drosophila: Technologies and applications.

Wiley interdisciplinary reviews. Developmental biology·2020
Same journal

Proximity-dependent labeling methods for proteomic profiling in living cells: An update.

Wiley interdisciplinary reviews. Developmental biology·2020
See all related articles

Related Experiment Video

Updated: May 8, 2026

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

Limb regeneration.

András Simon1, Elly M Tanaka

  • 1Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. Andras.Simon@ki.se.

Wiley Interdisciplinary Reviews. Developmental Biology
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

Animal limb regeneration varies across species. This study explores conserved mechanisms in amphibians like newts, axolotls, and frogs, examining tissue interactions and evolutionary context for limb regrowth.

More Related Videos

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration
04:24

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration

Published on: June 24, 2020

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
07:17

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

Published on: January 29, 2020

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration
04:24

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration

Published on: June 24, 2020

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
08:08

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation

Published on: January 12, 2022

Area of Science:

  • Comparative biology
  • Developmental biology
  • Regenerative medicine

Background:

  • Limb regeneration is a remarkable biological process observed in various animal species, with differing abilities across development.
  • Understanding the underlying mechanisms of limb regeneration is crucial for advancing regenerative medicine and comparative biology.

Purpose of the Study:

  • To investigate the conserved mechanisms of limb regeneration in tetrapods.
  • To explore the similarities and differences between limb regeneration and limb development.
  • To place the findings within an evolutionary context.

Main Methods:

  • Focus on three model amphibians: newts, axolotls, and frogs.
  • Review of recent research on tissue interactions during limb regeneration.
  • Comparative analysis of regeneration strategies across species.

Main Results:

  • Identified key tissue interactions essential for successful limb regeneration in amphibians.
  • Highlighted conserved molecular and cellular pathways involved in regeneration.
  • Provided insights into the evolutionary trajectory of limb regeneration capabilities.

Conclusions:

  • Tetrapod limb regeneration, particularly in amphibians, offers valuable insights into conserved biological mechanisms.
  • Understanding these mechanisms can inform strategies for tissue repair and regeneration in other contexts.
  • Evolutionary comparisons reveal both distinct and unifying principles in limb replacement strategies.